Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2175
Gene Symbol: FANCA
FANCA 		0.530 GenomicAlterations disease CGI
Entrez Id: 2176
Gene Symbol: FANCC
FANCC 		0.520 GenomicAlterations disease CGI
Entrez Id: 2177
Gene Symbol: FANCD2
FANCD2 		0.510 GenomicAlterations disease CGI
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD-transformed hematopoietic cells. 14604974 2004
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Prolonged exposure to FLT3 inhibitors leads to resistance via activation of parallel signaling pathways. 17047150 2007
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA 		1.000 CausalMutation disease CLINVAR
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. 22504183 2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CGI
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. 11290608 2001
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation. 22368270 2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Recurring mutations found by sequencing an acute myeloid leukemia genome. 19657110 2009
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR [FMS-like tyrosine kinase 3 gene mutations in acute myeloid leukemia]. 19840437 2009
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA 		1.000 CausalMutation disease CGI
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Impact of FLT3 mutations and secondary cytogenetic changes on the outcome of patients with newly diagnosed acute promyelocytic leukemia treated with a single agent arsenic trioxide regimen. 17606455 2007
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR MicroRNAs in liver disease. 22504185 2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Phase IIB trial of oral Midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3. 20733134 2010
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. 22504184 2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518. 15256420 2004
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD. 23430109 2013
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Prospective evaluation of gene mutations and minimal residual disease in patients with core binding factor acute myeloid leukemia. 23321257 2013
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR The importance of relative mutant level for evaluating impact on outcome of KIT, FLT3 and CBL mutations in core-binding factor acute myeloid leukemia. 23783394 2013
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Mutational landscape of AML with normal cytogenetics: biological and clinical implications. 23261068 2013
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy. 16857985 2006
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression. 15374878 2005